{"id":3190,"date":"2016-10-30T00:48:15","date_gmt":"2016-10-30T07:48:15","guid":{"rendered":"http:\/\/purepuer.com\/blog\/?p=3190"},"modified":"2016-10-30T00:48:15","modified_gmt":"2016-10-30T07:48:15","slug":"pu-erh-tea-polysaccharides-decrease-blood-sugar-by-inhibition-of-glucosidase-activity-in-vitro-and-in-mice","status":"publish","type":"post","link":"https:\/\/tepuer.com\/blog\/?p=3190","title":{"rendered":"Pu-erh tea polysaccharides decrease blood sugar by inhibition of ?-glucosidase activity in vitro and in mice"},"content":{"rendered":"<p>Food Funct. 2015 May;6(5):1539-46. doi: 10.1039\/c4fo01025f.<br \/>\nPu-erh tea polysaccharides decrease blood sugar by inhibition of ?-glucosidase activity in vitro and in mice.<br \/>\nDeng YT1, Lin-Shiau SY, Shyur LF, Lin JK.<br \/>\nAuthor information<br \/>\nAbstract<\/p>\n<p>Type 2 diabetes is mainly induced by environmental factors such as being overweight, decreased physical activity and inbalanced energy metabolism, such as pancreatic beta-cell dysfunction and peripheral insulin resistance. Acarbose, a microbial carbohydrate and an alpha-glucosidase inhibitor, is currently a useful agent for attenuating type 2 diabetes. However, it is usually accompanied by many side effects, such as abdominal distention, flatulence, diarrhea and meteorism. These side effects may be caused by its strong inhibition of alpha-amylase, leading to the accumulation of several undigested carbohydrates. The bacteria residing in the colon can further ferment the undigested carbohydrate to release gas. Finding a new alpha-glucosidase inhibitor with a low inhibitory effect on alpha-amylase is highly anticipated. In this report we describe a group of carbohydrates found in pu-erh tea polysaccharide (PTPS) that can inhibit alpha-glucosidase but have less of an inhibitory effect on alpha-amylase. The preliminary experiments on mice indicate that PTPS might be better than acarbose at suppressing blood glucose after oral administration of a carbohydrate diet; it is recommended that further clinical trials are required in type 2 diabetes in future studies. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Food Funct. 2015 May;6(5):1539-46. doi: 10.1039\/c4fo01025f. Pu-erh tea polysaccharides decrease blood sugar by inhibition of ?-glucosidase activity in vitro and in mice. Deng YT1, Lin-Shiau SY, Shyur LF, Lin JK. Author information Abstract Type 2 diabetes is mainly induced by environmental factors such as being overweight, decreased physical activity and inbalanced energy metabolism, such as [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"spay_email":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/tepuer.com\/blog\/index.php?rest_route=\/wp\/v2\/posts\/3190"}],"collection":[{"href":"https:\/\/tepuer.com\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tepuer.com\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tepuer.com\/blog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tepuer.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3190"}],"version-history":[{"count":1,"href":"https:\/\/tepuer.com\/blog\/index.php?rest_route=\/wp\/v2\/posts\/3190\/revisions"}],"predecessor-version":[{"id":3191,"href":"https:\/\/tepuer.com\/blog\/index.php?rest_route=\/wp\/v2\/posts\/3190\/revisions\/3191"}],"wp:attachment":[{"href":"https:\/\/tepuer.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3190"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tepuer.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3190"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tepuer.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3190"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}